Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They are really uncommon With this malignancy in comparison with other lymphoid neoplasms. CHD2 is mutated in five% of CLL and 7% of MBL.75 The histone methyltransferase SETD2 and ARID1A also are mutated in a small proportion of individuals. Of Observe,